Elucidation of DNA Primase as a Drug Target in Leishmania donovani: Structure-Guided Inhibitor Identification and Biochemical Validation. (PubMed, Chem Biol Drug Des) - Jul 26, 2026 - "Moreover, kinetic studies showed that Pritelivir and EGCG exhibit competitive and uncompetitive inhibition, respectively, for both NTP and DNA substrates. Pritelivir effectively disrupted the L. donovani cell cycle, and the replication mechanism in treated promastigotes showed irregular shapes and short flagella."
Journal • Infectious Disease
|
|
Anupama Sharma; Deep Bhowmik; Diwakar Kumar; Ravi Prakash Arya
|