Cytomegalovirus infection and drug resistance emergence during letermovir salvage therapy in a pediatric SCID patient. (PubMed, NPJ Antimicrob Resist) - May 29, 2025 - "Sequencing of viral DNA polymerase (DP; UL54), protein kinase (UL97), and terminase (UL51, UL56, UL89) genes identified ganciclovir (GCV) and foscarnet (PFA) resistance mutations in blood, but not cerebrospinal fluid. After treatment was shifted to cidofovir and letermovir (LMV), a LMV resistance mutation rapidly emerged in UL56 (C325F)...This case describes a CMV infection complicated by compartmentalization and the emergence of resistance to GCV, PFA, and LMV. It highlights the need for further investigation into alternative antiviral strategies for the prevention and treatment of CMV."
Journal • Cytomegalovirus Infection • Genetic Disorders • Immunology • Infectious Disease • Pediatrics • Primary Immunodeficiency
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Fien Horsten; Graciela Andrei; Pauline Mazilier; Pierluigi Calò; Piet Maes; Robert Snoeck; Sarah Gillemot
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