Role of Donor Cytomegalovirus Serostatus in CMV-Seronegative Recipients of Unrelated Donor Hematopoietic Cell Transplantation with PTCy prophylaxis. (PubMed, Transplant Cell Ther) - May 17, 2025 - "In CMV-seronegative adult AML patients undergoing unrelated donor HCT with PTCy, CMV-seropositive donors are associated with worse OS than CMV-seronegative donors, likely linked to higher relapse risk. These findings underscore the importance of considering donor CMV serostatus in donor selection for CMV-seronegative recipients undergoing HCT with PTCy. Further investigation is necessary to optimize donor selection strategies and improve outcomes in this patient population."
Journal • Acute Graft versus Host Disease • Acute Myelogenous Leukemia • Chronic Graft versus Host Disease • Cytomegalovirus Infection • Graft versus Host Disease • Hematological Malignancies • Immunology • Leukemia • Oncology • Transplantation
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Aleksandr Lazaryan; Christopher G Kanakry; Filippo Milano; Jennifer A Kanakry; Jennifer Saultz; Rohtesh S Mehta; Taha Al-Juhaishi; Yosra M Aljawai
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