Bidirectional transfer of pritelivir across term human placenta and its effect on placental functions. (PubMed, J Pharmacol Exp Ther) - May 7, 2025 - "Genital herpes in pregnancy is treated with nucleoside analog drugs such as acyclovir to reduce the risk of mother-to-neonate transfer of the virus. Although fetal exposure to the drug is plausible, pritelivir did not impact the viability and functionality of the placenta. Higher transplacental transfer of pritelivir in the fetal-to-maternal direction rather than maternal-to-fetal direction suggested the involvement of placental membrane transporters."
Journal • Breast Cancer • Herpes Simplex • Infectious Disease • Oncology • Solid Tumor
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Svetlana L Patrikeeva; Tatiana N Nanovskaya; Valentina F Bryant; Xiaoming Wang
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