β-Hydroxybutyric acid impairs host antimicrobial defense by targeting the CEACAM1-NADPH-ROS axis to disrupt macrophage bactericidal activity. (PubMed, Biochem Pharmacol) - Jun 10, 2026 - "In conclusion, we identify BHBA as an endogenous negative pharmacological ligand that directly targets CEACAM1 as a macrophage druggable receptor, thereby disrupting the NADPH-ROS bactericidal axis. This BHBA-CEACAM1-NADPH-ROS pharmacological cascade impairs host antimicrobial defense, providing a biochemically tractable target for the development of novel anti‑infective therapies."
Journal • Infectious Disease • Metabolic Disorders • CEACAM1 • CEACAM5 • CRP
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Dongping Li; Jiamin Li; Jianbin Guan; Jing Cai; Jingjing Yang; Ke Deng; Mingxia Li; Ping Chang; Sainan Chen; Shuntian Lei; Tao Zhong; Xingxing Liu; Zhanguo Liu; Zishan Peng
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