SUCCESSFUL HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACYCLOVIR-RESISTANT HSV INFECTION IN DOCK-8 DEFICIENCY (ESPID 2026) - May 28, 2026 - Abstract #EPV-0784; Pres time: Jun 1, 2026; 07:00 AM - 07:00 PM; Location: E-Poster Area; "HSV viremia persisted for 14 days despite acyclovir therapy, necessitating addition of Foscarnet, after which viremia cleared; viral resistance testing confirmed high-level Acyclovir/Cidofovir resistance...While novel treatments like Pritelivir was explored, progressive ocular deterioration and anticipated delay in drug procurement led to the risky decision to proceed with matched sibling donor hematopoietic stem cell transplantation for definitive immune reconstitution...Learning Points/Discussion The increasing prevalence of HSV resistance among immunocompromised patients presents a significant clinical challenge given the restricted arsenal of available antiviral agents, coupled with the potential toxicity and questionable effectiveness of current therapeutic options. Hematopoietic stem cell transplantation facilitates restoration of competent T-cell populations critical for infection control through correction of the primary immunologic defect."
Herpes Simplex • Infectious Disease
|
|
Moustafa . 1; Rao K. 1; Breuer J. 2; Rivers E. 1
|