Human cytomegalovirus terminase inhibitors letermovir, tomeglovir, and the halogenated benzimidazoles modify DNA cleavage/packaging to generate a super-genomic DNA species by cleavage site skipping. (PubMed, Antiviral Res) - May 22, 2026 - "These findings suggest that, despite structural differences, terminase inhibition involves altered cleavage site recognition, resulting in packaging of abnormal DNA species within nuclease-permeable capsids. Discovery of additional terminase inhibitors may reveal distinct mechanisms of inhibition and perhaps novel terminase functions."
Journal • Cytomegalovirus Infection • Transplantation
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Ahmed Al Qaffas; Amine Ourahmane; Anne Sauer; Desy Balalimbong; Dirk P Dittmer; Jian Ben Wang; Justin Landis; Michael A McVoy; Razia Moorad; Stephen J Dollery
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