Irisin promotes lipid clearance through the CD81-integrin-FAK axis in steatotic hepatocytes. (PubMed, J Physiol Biochem) - Oct 19, 2026 - "Conversely, FAK inhibition using BI 853520 or CD81 knockdown abrogated these protective anti-steatotic effects. In conclusion, CD81 serves as a functional co-receptor that physically associates with the integrin αV/β5 complex to amplify irisin-FAK signaling, restrict PPARγ nuclear transactivation, and suppress lipid droplet accumulation in cultured hepatocytes in vitro. These findings highlight the CD81-integrin-FAK axis as a potential candidate for further translational exploration in MASLD."
Journal • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • CD81 • PLIN2 • PPARG
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Cheuk-Kwan Sun; Jian-Han Chen; Ming-Hong Tai; Po-Han Chen; Po-Huang Lee; Ying-Hsien Kao; Yo-Chen Chang; Yu-Chun Lin
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