Real World Effectiveness and Safety of Upadacitinib in Giant Cell Arteritis (ACR Convergence 2026) - Sep 8, 2026 - Abstract #184; Pres time: Nov 8, 2026; 10:30 AM - 12:30 PM; Location: WB1&2; In Person; "Background/Purpose: Patients with giant cell arteritis (GCA) frequently relapse despite treatment with glucocorticoids, methotrexate, or tocilizumab (TCZ)...Before starting UPA, prior csDMARD exposure included methotrexate (n=31; 49.2%), leflunomide (n=4; 6.3%), and hydroxychloroquine (n=1; 1.6%). Prior biologic and/or JAK inhibitor treatments were: TCZ (n=40; 63.5%), sarilumab (n=3; 4.8%), abatacept (n=4; 6.3%), TNF inhibitors (n=3; 4.8%), ustekinumab (n=1; 1.6%), secukinumab (n=3; 4.8%), rituximab (n=3; 4.8%), baricitinib (n=6; 9.5%), and tofacitinib (n=1; 1.6%)... This real‑world analysis suggests that UPA may be effective and relatively safe in GCA, including patients refractory to multiple therapies such as MTX, biologic agents, or other JAK inhibitors. These findings extend SELECT GCA by providing evidence in a broader, clinically unstable population, many of whom were refractory to TCZ and not represented in clinical trials. TABLE."
Clinical • Real-world • Real-world effectiveness • Real-world evidence • Acute Myelogenous Leukemia • Brain Cancer • Giant Cell Arteritis • Glioblastoma • Hematological Malignancies • Herpes Zoster • Immunology • Infectious Disease • Leukemia • Nephrology • Pulmonary Embolism • Respiratory Diseases • Septic Shock • Solid Tumor • Varicella Zoster
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Fabricio Benavides1; Adrián Martín-Gutiérrez2; Javier Loricera3; Tofade Toluwalase4; Eva Galindez-Agirregoikoa5; Eugenio De Miguel6; Cristina Campos Fernández7; Patricia Moya-Alvarado8; Susana Romero Yuste9; Dalifer Freites Núñez10; Anne Riveros-Frutos11; Judit Font12; Olga Maiz13; Olga Rusinovich Lovgach14; Clara Moriano Morales15; Helena Codes-Méndez16; Carolina Corral-Cuadrado17; Ana Urruticoechea-Arana18; CRUZ FERNANDEZ ESPARTERO19; Maria Laino20; Vicente Aldasoro Caceres20; Adela Gallego Flores21; Juan Molina-Collada22; Paula Valentina Estrada Alarcón23; Patricia León Torralba24; M NOELIA ALVAREZ RIVAS25; Teresa Clavaguera26; BORIS A. BLANCO CACERES27; CARMEN SECADA-GÓMEZ28; Sebastian Unizony29; Ricardo Blanco30
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