Single-cell Unperturbed Activation Profiling by mass cytometry captures in vivo immune signaling in SLE. (PubMed, Front Immunol) - Sep 2, 2026 - "We further explored the utility of UACT for treatment monitoring in four SLE patients treated with the JAK inhibitor baricitinib under compassionate use, where baseline pSTAT3 levels across multiple cell subsets seemed to be associated with treatment response. Our results thus demonstrate that single-cell UACT without restimulation of cells can detect immune activation in chronic inflammatory diseases, supporting both biomarker discovery and the identification of novel therapeutic targets."
Biomarker • Journal • Preclinical • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Rheumatology • Systemic Lupus Erythematosus • CD8
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Adrian Barreno-Sanchez; Amro Abbas; Andreas Grützkau; Axel R Schulz; Heike Hirseland; Henrik E Mei; Lennard Ostendorf; Marie Burns; Robert Biesen; Sabine Baumgart; Sebastian Ferrara; Stefan Frischbutter; Tobias Alexander
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