Iclusig (ponatinib) - Takeda
Scemblix (asciminib) - Novartis
Reduced Mortality, Cytopenias, and Cardiovascular Events With Asciminib Compared With Ponatinib in Previously Treated Chronic Myeloid Leukemia: A Propensity-Matched Real-World Analysis (SOHO 2026) - Sep 1, 2026 - Abstract #CML-1365; Location: LEVEL 3, HALL B3; "In this large propensity-matched real-world study, asciminib was associated with significantly lower mortality, hematologic toxicity, thromboembolic complications, and cardiovascular events compared with ponatinib in previously treated CML. These findings support asciminib as a potentially safer therapeutic strategy for patients requiring later-line therapy." 
Clinical • Real-world • Real-world evidence • Chronic Myeloid Leukemia • Hematological Malignancies • Leukemia • Oncology • ABL1 • BCR
https://www.sciencedirect.com/science/article/abs/pii/S215226502602197X
 
Layal Sharrouf MD
 
Sep 1, 2026
 
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