Diagnosing Musculoskeletal GVHD in the Setting of Allogenic Stem Cell Transplant (SOHO 2026) - Sep 1, 2026 - Abstract #CT-1064; "Case: A 72-year-old patient with myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) presented with severe bilateral hip and knee pain with diffuse synovitis beginning on day +44 following 10/10 MUD allo-HSCT with fludarabine/melphalan reduced-intensity conditioning...The patient was presumptively treated for musculoskeletal GVHD with high-dose corticosteroids and ruxolitinib, with steroid taper... This case underscores the diagnostic challenge of GVHD in the setting of allo-HSCT, especially in the setting of possible concurrent CIPS. Diagnosis requires exclusion of infection, avascular necrosis, and connective tissue disease. Clinicians should maintain a high index of suspicion for musculoskeletal GVHD in transplant recipients presenting with unexplained polyarthralgia, even in the absence of classic GVHD target organ involvement."
Hematological Malignancies • Myelodysplastic Syndrome • Myeloproliferative Neoplasm • Oncology
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Rafia Ali MD; Saagar Pamulapati MD; Nikhita Vemulapalli DO; Yogesh Jethava MD; Sherjeel Sana MD
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