Acute Pericarditis as the Initial Manifestation of Philadelphia Chromosome–Positive B-Cell Acute Lymphoblastic Leukemia (SOHO 2026) - Sep 1, 2026 - Abstract #ALL-873; "The patient received corticosteroids followed by ponatinib, blinatumomab, and alternating intrathecal methotrexate and cytarabine for central nervous system prophylaxis. Cardiac manifestations of acute leukemia are rare and may precede hematologic diagnosis. This case highlights acute pericarditis as an unusual presenting manifestation of PH+ B-ALL with p210 BCR::ABL1 transcript and IKZF1 deletion, molecular features associated with higher-risk disease biology. The initial dry tap complicated diagnosis and emphasizes the importance of integrating peripheral flow cytometry with molecular testing in patients with unexplained cytopenias and inflammatory serosal disease."
Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Hematological Malignancies • Leukemia • Oncology • ABL1 • BCR • CD34 • CD79A • CRP • IKZF1 • MME
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Tamara Pyatnitskaya MD; Moana Da Silva Santiago MD; Shivani Garlapati MBBS; Tanisha Mishra MBBS
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