A gellan gum-based in situ gel for prolonged ocular retention of ruxolitinib in dry eye disease. (PubMed, Int J Biol Macromol) - Sep 1, 2026 - "While blank gel provided physical protection and reduced pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) possibly through lubrication and barrier effects, Ru-loaded gel uniquely promoted histological recovery of corneal epithelium and conjunctival goblet cells. These findings demonstrate that the engineered Ru gel is a safe and potent therapeutic platform that enhances ocular exposure and mitigates inflammation through prolonged retention and pharmacological repair, offering a promising strategy for DED management."
Journal • Dry Eye Disease • Inflammation • Ocular Inflammation • Ophthalmology • IL1B • IL6 • TNFA
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Qiao Wang; Qiao Zeng; Wenying Yu; Xinghao Chen; Xu Chen; Zhan Tang
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