Ruxolitinib prevents irreversible autoimmune endocrinopathies in APECED. (PubMed, Nat Commun) - Aug 31, 2026 - "These findings provide clinical evidence that timely JAK-STAT pathway inhibition can intercept evolving endocrine autoimmunity in APECED. More broadly, they advance a disease-interception paradigm in which early, pathway-directed cytokine blockade may alter the natural history of autoimmune endocrinopathies."
Journal • Candidiasis • Endocrine Disorders • Hypoparathyroidism • Immunology • Inflammation • IFNG
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Aaron Bennett; Benjamin Colton; Heather Moorman; Herodes Guzman; Joseph Pechacek; Karen K Winer; Kathleen Loomes; Lindsey B Rosen; Lucas Dos Santos Dias; Maria Sacta; Michail S Lionakis; Neil Romberg; Niamh McGrath; Peter D Burbelo; Princess Barber; Rachel Wu; Shana E McCormack; Stefania Pittaluga; Steven M Holland; Taura Webb; Theo Heller
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