Three-in-One: Immune-Effector Cell Enterocolitis With Concurrent Clostridioides difficile Infection and Cytomegalovirus Viremia (ACG 2026) - Aug 29, 2026 - Abstract #P3597; Pres time: Oct 12, 2026; 10:30 AM - 04:15 PM; Location: Exhibit Halls A - D (Level 3); "Introduction: Immune effector cell-associated enterocolitis (IEC-EC) is a rare complication of B-cell maturation antigen-directed chimeric antigen receptor T-cell (CAR-T) therapy, particularly ciltacabtagene autoleucel or Carvykti...Despite oral vancomycin, symptoms persisted...She was treated with budesonide followed by intravenous methylprednisolone without improvement...Due to persistent symptoms despite corticosteroids, ruxolitinib was subsequently initiated, resulting in improvement of diarrhea, discontinuation of parenteral nutrition, and eventual discharge...AI was used in formatting of this article. Figure: Figure 1: A- Body of the stomach with friability on EGD, B- Congested and edematous mucosa of colon Figure: Figure 2: A- Small bowel with crypt loss, 10x, B- Small bowel with apoptotic bodies and plasma cell depletion, 20x, C- Colon with apoptotic bodies and plasma cell depletion, 20x"
Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Infectious Disease • Multiple Myeloma
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Jenny Joseph MBBS 1; Tejasav Sehrawat MD 2; Madison Perogoy MD 2; Fatima Khan MD 3; Michelle L Hughes MD 2; Wenyi Luo MD PhD 4; Kenneth W. Hung MD 2
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