When the Barrier Breaks: Fatal Invasive Candida Guilliermondii Colitis in Severe Gastrointestinal GVHD (ACG 2026) - Aug 29, 2026 - Abstract #P0379; Pres time: Oct 11, 2026; 03:30 PM - 07:00 PM; Location: Exhibit Halls A - D (Level 3); "Case Description/ A 43-year-old patient with relapsed mixed phenotype acute leukemia underwent second allogeneic stem cell transplant with double 4/8 umbilical cord donors after Flu/Mel conditioning and cyclosporine/MMF prophylaxis...Necrosis raised concern for fungal colitis, prompting isavuconazole and ruxolitinib escalation to 10 mg BID...Despite antibiotics, micafungin/isavuconazole, and vedolizumab, she died from recurrent GI bleeding due to Candida superinfection of severe, treatment-refractory GVHD enterocolitis...Figure: Figure 2. Laboratory trends through the course"
Candidiasis • Gastroenterology • Gastrointestinal Disorder • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Leukemia
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Aleena Saifullah BA 1; Jennifer Claytor MD MS 2
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