Regulation of Ferroptosis in Human Macrophage by Nitric Oxide Donors. (PubMed, Sovrem Tekhnologii Med) - Jul 17, 2025 - "RSL3 and ML-162, inhibitors of glutathione peroxidase 4 (GPX4), and erastin, an inhibitor of cystine/ glutamate transport, were used to induce ferroptosis in THP-1 macrophages. DEA had no effect on THP-1 macrophage ferroptosis, whereas DPTA completely inhibited ferroptosis. DTPA, being an NO donor with a half-life of 3 h at 37°С, can be used to inhibit ferroptosis in THP-1 macrophages, which develops within 17-19 h. Therefore, there are mechanisms of prolongation of NO action in cells that should be studied to use NO donors for regulation of cellular ferroptosis."
Journal • Hematological Malignancies • Leukemia • Oncology • GPX4
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A A Zolotopup; I I Vlasova; M D Yurkanova; P S Timashev; T O Klyucherev
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