LncRNA TMPO-AS1 facilitates cervical cancer cell tumorigenesis and ferroptosis resistance via interaction with LCN2. (PubMed, Sci Rep) - Jul 2, 2025 - "TMPO-AS1 decreased the lipid reactive oxygen species, intracellular Fe2+, and malondialdehyde content, leading to the inhibition of sulfasalazine- and erastin-induced ferroptosis. Furthermore, LCN2 regulated the expression of solute carrier family 7 member 11 by interacting with the splicing factor proline and glutamine-rich. Our study illustrates that TMPO-AS1 functions as a tumorigenic regulator and may be a promising therapeutic target for CESC patients with high TMPO-AS1 expression."
Journal • Cervical Cancer • Cervical Squamous Cell Carcinoma • Oncology • Solid Tumor • Squamous Cell Carcinoma • LCN2 • SLC7A11 • TMPO-AS1
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Chunxiu Peng; Jian He; Jintong Na; Liangliang Wu; Xu Liu; Ying Ju; Yuan Liao; Zhiyong Zhang; Zhuoran Wang
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