Induction of ferroptosis and senescence in epithelial ovarian cancer cell line: Implications of targeted therapeutic strategies (EACR 2025) - Jun 29, 2025 - Abstract #P-227; Pres time: Jul 18, 2025; 10:45 AM - 08:00 PM; Location: Poster and Exhibition Hall; Poster Board No EACR25-2301; "This study investigates the effects of senescence and ferroptosis inducers on two distinct epithelial ovarian cancer (EOC) cell lines, SKOV-3 and OVCAR-3, using qPCR to assess the expression of various biomarkers.Material and SKOV-3 and OVCAR-3 EOC cell lines were treated with ferroptosis inducers (RSL3, Erastin, FSP1i, Brequinar) and senescence inducers (Etoposide, Olaparib, Carboplatin, Cisplatin). This study highlights the potential of targeting both senescence and ferroptosis in epithelial ovarian cancer. Ferroptosis-related biomarkers, such as NCOA4 and CP, were modulated independently of cell line, indicating a common response to ferroptosis induction. Senescence was more cell line-dependent, with CDKN1A and CDKN2A serving as markers of senescence induction in OVCAR-3."
Preclinical • Epithelial Ovarian Cancer • Oncology • Ovarian Cancer • Solid Tumor • CDKN1A • CDKN2A • CXCL8 • IL6 • NCOA4
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L. Berjawi 1; F. Alarcon 2; I. Lopez 2; S. Lucio 2; R. Mato 2; M. Quindos 3; M. Quintela 4; A. Vizoso 2; M. Arufe 5; C. 2024 5
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