Microneedle-mediated delivery of Iron Oxide Nanoparticles & Oxaliplatin with immune checkpoint inhibitors for its induction of ferroptosis and immunomodulation in Head and neck squamous cell carcinoma (EACR 2025) - Jun 29, 2025 - Abstract #P-409; Pres time: Jul 17, 2025; 10:45 AM - 08:00 PM; Location: Poster and Exhibition Hall; Poster Board No EACR25-1702; "Apoptosis induction was higher in Oxaliplatin with Annexin V + cells (30%) than DLIN (14%) or Erastin (9%) as compared to untreated (5%)... IONP NPs has shown significant cytotoxicity with ferroptosis induction in cancer cells which was comparable to Oxaliplatin. The synergistic effect of the MN-mediated delivery of IONP/Oxali with the immune checkpoint inhibitors had enhanced cytotoxicity in tumor cells which could be targeted in cancer therapeutics strategies."
Checkpoint inhibition • Immunomodulating • IO biomarker • Head and Neck Cancer • Immunology • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • ANXA5 • CASP3 • CD4 • CD8 • GPX4 • MT-CO2
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D. Tripathy 1; J. Crane 2; R. Kishan 1; X. Lan 3; J. Zhong 1; W. Zhou 1; J. Rivas 2; R. Su 1
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