Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer. (PubMed, Oncotarget) - Jun 25, 2025 - "Here, we show that hypoxia dramatically reduces the sensitivity of PCa cell lines to mechanistically distinct FINs, Erastin (xCT inhibitor) and RLS3 (GPX4 inhibitor) by inducing lipid droplet (LD) accumulation...Targeting LD biogenesis and de novo lipogenesis did not alter sensitivity to RSL3 under hypoxia. These findings suggest that hypoxia promotes ferroptosis resistance in PCa by altering lipid metabolism at the transcriptional level, by producing lipids that are less susceptible to peroxidation, and at the cellular level, by increasing storage in LDs. Thus, manipulating LD dynamics represents a promising strategy to overcome hypoxia-induced resistance to ferroptosis and improve the success of PCa treatment."
Journal • Genito-urinary Cancer • Metabolic Disorders • Oncology • Prostate Cancer • Solid Tumor • ACSL4 • GPX4
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Andres D Vizzerra; Ashley J Snider; Caitlyn E Flores; Hope Liou; Justin M Snider; Noel A Warfel; Shailender S Chauhan
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