SUMO2 inhibits ACSL3 protein degradation to antagonize erastin-induced ferroptosis in hepatocellular carcinoma. (PubMed, Discov Oncol) - Jun 17, 2025 - "In summary, SUMO2 binds to ACSL3, preventing its protein degradation, thereby increasing its protein stability and level, which in turn negatively regulates ferroptosis in HCC cells. These results point to interesting targets and therapeutic approaches for HCC."
Journal • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • ACSL3
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Bin Ye; Chuanfei Li; Yanxi Shen
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