The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis. (PubMed, Discov Oncol) - Jun 12, 2025 - "HSPB1 promotes pancreatic cancer progression by suppressing TP53 signaling and increasing SLC7A11 and GPX4 expression, attenuating ferroptosis. These insights suggest HSPB1 as a potential therapeutic target, warranting further development of specific inhibitors."
Journal • Oncology • Pancreatic Cancer • Solid Tumor • GPX4 • HSPB1 • SLC7A11 • TP53
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Jihui Luo; Jing Qu; Ning Ning; Qi Liu; Zeyu Tian
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