RAB3IL1: A Key Regulator in the Autophagy-Ferroptosis Axis of Male Infertility. (PubMed, Biol Reprod) - Jun 12, 2025 - "Using the ferroptosis inducer erastin, an antagonist of the cystine antiporter SLC7A11, we established a ferroptosis model in mouse Sertoli cells, demonstrating that ferroptosis activation led to cytoskeletal disarray and BTB disruption, accompanied by excessive autophagy activation...Mechanistically, Rab3il1 knockdown induced ferroptosis via translocation of SLC7A11, resulting in cytoskeletal defects and BTB damage. Our findings underscore the critical role of the ferroptosis-autophagy axis, regulated by RAB3IL1, in preserving the spermatogenic microenvironment, offering a potential therapeutic target for restoring spermatogenesis in iNOA patients."
Journal • Infertility • Sexual Disorders • SLC7A11
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Binyu Ma; Mei Wang; Xuanyi He; Ying Gao; Yingjing Wan; Yuanzhen Zhang; Zhidan Hong
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