Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer. (PubMed, Acta Pharm Sin B) - Jun 9, 2025 - "Moreover, Spd and erastin significantly inhibit proteasome activity which results in a decrease in proteasomal degradation of NRF2, although many proteasome-related genes are induced either by Spd or Spd plus erastin. Thus, in addition to its pro-oncogenic activity, the supplement of Spd improves antitumor activity in combination with ferroptosis inducers and offers an optional approach to cancer treatment."
Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • HMOX1
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Dan Feng; Hongxiang Lou; Huanmin Niu; Huiqing Yuan; Jian Zhang; Jing Wang; Mengqi Jia; Qi Sun; Qiqi Lu; Wenxue Guo; Xiaoxue Zheng
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