Gallium disrupts endoplasmic reticulum iron metabolism to induce lipid metabolic reprogramming in glioblastoma cells. (PubMed, iScience) - Jun 5, 2025 - "Moreover, Ga(NO3)3 enhances the toxicity of the ferroptosis inducer, erastin, and decreases cell stiffness, indicating an exacerbation of ferroptosis...Lipidomic analysis revealed a significant increase in oxidizable triglycerides following Ga(NO3)3 treatment. Thus, it appears that Ga(NO3)3 exacerbates ferroptosis in glioblastoma cells by disrupting the di-ferric lipid metabolic regulator SCD and warrants further investigation as an alternate mechanism of action for Ga-based therapy."
Journal • Brain Cancer • Glioblastoma • Metabolic Disorders • Oncology • Solid Tumor • SCD
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Akalanka B Ekanayake; Alexei V Tivanski; Amira Zaher; Cristina M Furdui; Jeffrey M Stolwijk; Jingyun Lee; John Cooke; Michael S Petronek; Stephenson B Owusu
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