Alliin from garlic as a neuroprotective agent attenuates ferroptosis in vitro and in vivo via inhibiting ALOX15. (PubMed, Food Funct) - May 21, 2025 - "The results showed that alliin significantly inhibited erastin-induced ferroptosis in HT22 cells and suppressed ferroptosis in the brain tissue of collagenase-induced ICH mice, alleviating neurological dysfunction and pathological damage...This study is the first to demonstrate that alliin regulates ferroptosis both in vitro and in vivo. In conclusion, our study highlights ALOX15 as a critical factor in ferroptosis associated with ICH, and shows that alliin exerts neuroprotective effects by inhibiting ALOX15-dependent ferroptosis."
Journal • Preclinical • Cerebral Hemorrhage • Hematological Disorders • ALOX15
|
|
Chengquan Wen; Jianfeng Chu; Junjun Meng; Lei Feng; Pei Jiang; Ruili Dang; Wenxiu Han; Xiaofan Fan; Yang Lu
|