Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion. (PubMed, Redox Biol) - May 13, 2025 - "This effect was observed in both in vitro and in vivo models, including erastin-induced ferroptosis across multiple cell lines and acetaminophen overdose-triggered ferroptosis in hepatocytes...Targeting TFRC using GalNAc-siTfrc mitigated acetaminophen-induced liver injury in vivo. In conclusion, our study provide evidence that availability of glutathione pools affects protein S-glutathionylation and regulates protein functions to influence the process of ferroptosis, which opens an avenue to understanding the cell ferroptosis induced by glutathione depletion."
Journal • Hepatology • Liver Failure • CHAC1
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Baolin Niu; Haiteng Deng; Liu Yu; Nanbin Zhu; Qingling Xu; Tao Yang; Xiaobo Li; Xiaokai Wang; Xiaolin Tian; Xiaoming Yang; Xiaoyun Li; Xuening Wang; Yang Zhi; Yi Ju; Yimin Mao; Yiming Qiao; Yinuo Dong; Yixuan Wu; Yufan Zheng; Yuting Zhang; Zhuolin Liu
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