JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 Axis. (PubMed, Sci Rep) - May 9, 2025 - "The cytotoxic effects of erastin and JS-K were evaluated in various renal cell carcinoma (RCC) cell lines and normal human renal epithelial cells...In addition, JS-K induced ferroptosis in RCC cells by reducing cellular GSH levels, increasing lipid peroxidation, and elevating ferrous ion levels, and the effects of JS-K were neutralized by N-acetylcysteine (NAC)...Finally, JS-K inhibited tumor growth in a mouse model by inducing ferroptosis. JS-K induces ferroptosis in RCC cells by depleting glutathione through the inhibition of the c-Myc-GSTP1 axis."
Journal • Genito-urinary Cancer • Kidney Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • GSTP1 • MYC
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Bailiang Miu; Bin Li; Jianjun Liu; Jingping Qiu; LuGang Zhu; Sheng Gao; Xinghua Lin; Yuwan Zhao
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