L-theanine prevents myocardial injury in sleep‑deprived mice by suppressing ferroptosis through SIRT1. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - May 7, 2025 - "This study utilized a modified multiple-platform water environment method to establish an SD model and induce a ferroptosis model in H9c2 cells pretreated with erastin. Notably, the SIRT1 inhibitor EX-527 can counteract the protective effect of L-theanine against ferroptosis in cardiomyocytes. These findings highlight that L-theanine mitigates SD-induced cardiac injury primarily by suppressing ferroptosis through SIRT1 in cardiomyocytes."
Journal • Preclinical • Cardiovascular • SIRT1
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Mingrui Li; Xinglong Lu; Xuanxuan Huang; Yi Wu; Yin Cao; Yuping Miao; Zhenghua Wu; Zhongwen Xie; Zipeng Gong
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