Berberine alleviates tendinopathy by suppressing the cGAS-STING pathway and Relieving ferroptosis. (PubMed, Biochem Biophys Res Commun) - May 5, 2025 - "To validate these findings further, we administered the ferroptosis inducer Imidazole Ketone Erastin (IKE) to evaluate the effects of berberine. IKE significantly diminished the therapeutic effects of berberine on tendinopathy, as indicated by the previously mentioned markers. Thus, berberine mitigated ferroptosis by inhibiting the cGAS-STING pathway, highlighting its potential in managing tendinopathy."
Journal • GPX4
|
|
Haibin Zhou; Huan Liu; Mingyuan Song; Shaojie Yang; Wenting Wei; Xingquan Xu; Yang Lu; Yeshuai Shen
|