In Situ Investigation of Intercellular Communication in Ferroptosis Integrated Scanning Electrochemical Microscopy with Microfluidic Devices. (PubMed, ACS Sens) - Apr 29, 2025 - "By in situ monitoring the changes of key parameters (ROS, glutathione (GSH), and cell membrane permeability) in Erastin-induced ferroptosis, it was found that TAMs partially restored the reduced GSH efflux, increased ROS release, and impaired cell membrane barrier in TNBCs, indicating that TAMs can suppress TNBC ferroptosis...After inhibition of STAT3, increased ROS release and membrane permeability as well as decreased GSH efflux of TNBCs were in situ monitored by SECM, demonstrating the intercellular communication mechanism in ferroptosis. Therefore, this work provides a potential strategy of targeting TAMs for ferroptosis-based TNBC therapy."
Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer
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Fan Zhang; Feng Tu; Ping Geng; Qingjiang Wang; Xin Li; Yuqi Lu; Yuxi Ge
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