Glutathione Decreases Parkinsonism-Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells. (PubMed, Pharmacol Res Perspect) - Apr 27, 2025 - "The SH-SY5Y cells were divided into six groups: control, MPP, MPP + erastin, MPP + erastin + ferrostatin-1, MPP + erastin + glutathione (GSH), and MPP + erastin + TRPM2 blocker (ACA)...In conclusion, the increase in death and ferroptosis in parkinsonism (MPP)-induced SH-SY5Y cells was attributed to TRPM2 activation. By regulating cytosolic oxidant/antioxidant balance, GSH regulates TRPM2 channel activity and lowers neuronal death and ferroptosis."
Journal • CNS Disorders • Movement Disorders • Parkinson's Disease
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Ay?e Arzu Say?n ?akul; Elif Güzel
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