SLC7A11 is an unconventional H+ transporter in lysosomes. (PubMed, Cell) - Apr 27, 2025 - "A candidate screen on an orphan lysosome membrane protein (OLMP) library enabled us to discover that SLC7A11, the protein target of the ferroptosis-inducing compound erastin, mediates a slow lysosomal H+ leak through downward flux of cystine and glutamate, two H+ equivalents with uniquely large but opposite concentration gradients across lysosomal membranes...Correction of abnormal lysosomal acidity restored lysosome homeostasis and prevented ferroptosis. These studies have revealed an unconventional H+ transport conduit that is integral to lysosomal flux of protonatable metabolites to regulate lysosome function, ferroptosis, and Parkinson's disease (PD) pathology."
Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • SLC7A11
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Beisha Tang; Cheng Zhao; Dongdong Zhao; Enjun Xie; Fangqian Huang; Fudi Wang; Haoxing Xu; Hongxu Pan; Jingzhi Chen; Junsheng Yang; Junxia Min; Liding Zhao; Meiqin Hu; Na Wen; Nan Zhou; Ping Li; Siyu Liu; Wei Luo; Weijie Cai; Xiaotong Yang; Xinghua Feng; Xinhui Chen; Yaping Meng; Zhidong Cen; Zikai Jiang
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