Inhibition of VSMC Ferroptosis Mitigates Pathological Vascular Remodeling: A Novel Therapeutic Strategy for Abdominal Aortic Aneurysm. (PubMed, J Cardiovasc Transl Res) - Apr 27, 2025 - "Additionally, the ferroptosis inducer erastin and Ang II can both promoted pathological remodeling of abdominal aortic rings, but Fer-1 significantly suppressed these effects...Mechanistically, RNA-sequencing analysis revealed that Fer-1 regulates VSMC contractile function, suppresses inflammation, and mitigates extracellular matrix remodeling. These findings highlight the critical role of VSMC ferroptosis in AAA pathogenesis and demonstrate that ferroptosis inhibition effectively reduces pathological vascular remodeling, making it a promising therapeutic strategy for preventing AAA."
Journal • Cardiovascular • Inflammation
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Juan Peng; Man Li; Ni Gan; Qiong Xiang; Wen Zeng; Xi-Long Zheng; Xiaoyan Dai; Yanyu Chen; Yating Zhou; Yuting Cui; Zhihan Tang
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