Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferroptosis in Hippocampal Neurons Via Activating the Nrf2/GPX4/SLC7A11 Pathway. (PubMed, J Neuroimmune Pharmacol) - Apr 11, 2025 - "By in vitro experiments, erastin treatment exacerbated hippocampal neuronal damage, ferroptosis, mitochondrial damage, and lipid peroxidation; however, YNJY prescription abolished these erastin-induced effects...YNJY prescription relieves PSD by blocking ferroptosis via activating the Nrf2/GPX4/SLC7A11 pathway. It may be a promising agent for treating PSD clinically."
Journal • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry • GPX4 • SLC7A11
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Changmin Xu; Hongwei Liu; Jin Yao; Qisheng Tang; Ruizhen Zhao; Shuqing Liu; Yuan Zhang; Zechun Guo
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