Ferroptosis modulates melanoma progression in an age-specific manner through changes in the tumor microenvironment (AACR 2025) - Mar 26, 2025 - Abstract #2558; Pres time: Apr 28, 2025; 02:00 PM - 05:00 PM; Location: Section 2; Poster Board No: 12; "To understand how ferroptosis impacts tumor growth in young and aged mice, we used a syngeneic tumor model injecting Yumm1.7 cells intra-dermally and the treatment with a lipid peroxidation inducer (imidazole ketone erastin, IKE) or an inhibitor (Liproxstatin-1)...We are currently exploring how these treatments impacted metastatic dissemination, stromal architecture and sensitivity in BRAF/MEK-resistant tumors. These results indicate that ferroptosis modulation is a promising avenue for combined treatment with existing clinical strategies."
Biomarker • Tumor microenvironment • Melanoma • Oncology • Skin Cancer • Solid Tumor • AIFM2 • AXL • BRAF • CDKN1A • GPX4 • WNT5A
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Murilo Ramos Rocha; Yash Chhabra; Alexis E. Carey; Cheyenne Palm; Kevin Zhang; Edwin Kumah; Vania Wang; Laura Huser; Elizabeth I. Harper; Fan Huang; Ashani Weeraratna
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