GPX4-mediated Pathway Regulates Iron Efflux to Prevent Ferroptotic Cell Death and Promote Immunosuppressive Signals in Osteosarcoma Cells (AACR 2025) - Mar 26, 2025 - Abstract #1637; Pres time: Apr 28, 2025; 09:00 AM - 12:00 PM; Location: Section 17; Poster Board No: 24; "Erastin, an xCT inhibitor, and RSL3, a GPX4 inhibitor, induced ferroptotic cell death in these cells...We observed that combination treatment with dual MSPR and MET inhibitor, BMS-777607, showed synergistic effects with GPX4 inhibition...We also identified novel target, MSPR, regulated by GPX4 inhibition, which potentially contribute to the activation of immunosuppressive signals from osteosarcoma. In conclusion, this study underscores that targeting the ferroptotic pathway holds a great promise for therapeutic potential in osteosarcoma by regulating both intracellular pathway and the immunosuppressive tumor microenvironment."
Oncology • Osteosarcoma • Sarcoma • Solid Tumor • AKR1C1 • FTH1 • GPX4 • HMOX1 • NQO1
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Md Abdullah; Donghee Lee; Rong Li; Eslenur Nipa; Jong Hyuk Kim
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