Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer's Disease by Regulating the NOX4/Nrf2 Signaling Pathway. (PubMed, J Agric Food Chem) - Mar 22, 2025 - "NADPH oxidase 4 (NOX4) overexpression revealed that AS treatment inhibited NOX4, thereby reducing NOX4 stability and regulating the NOX4/Nrf2 pathway in erastin-injured HT22 cells and significantly alleviating ferroptosis. Therefore, AS inhibited ferroptosis and improved AD by rebuilding iron homeostasis and LPO balance in the brain. AS has the potential to be a promising candidate medicine for AD."
Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • GPX4 • NOX4 • SLC7A11
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Adnan Mohammed Algradi; Anam Naseem; Bingyou Yang; Haixue Kuang; Lili Zhang; Mengmeng Li; Min Wang; Qingshan Chen; Siyi Wang; Wei Guan; Xu Yang; Yan Liu; Yikai Jiang; Zhichao Hao
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