Time Series Imaging the Mitochondrial Microenvironment and Its Interactions with Lysosomes during Ferroptosis. (PubMed, Anal Chem) - Mar 14, 2025 - "Using the developed IMT, we observed an increase in mitochondrial viscosity during erastin-induced ferroptosis and a decrease during ferrostatin-1-inhibited ferroptosis...In addition, combined with LGT, we visualized the dynamic process of first contact and then separation between lysosomes and mitochondria during ferroptosis, confirming the complexity and variability of MLIs. This work not only enhances our understanding of the complex biochemical processes underlying ferroptosis but also opens new avenues for therapeutic intervention in diseases characterized by this form of cell death."
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Cuimin Feng; Junling Yin; Tian Cheng; Tianshuo Xing; Xinyu Shao; Xueying Zheng; Xusheng Ren
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