Ferroptosis enhances the therapeutic potential of oncolytic adenoviruses KD01 against cancer. (PubMed, Cancer Gene Ther) - Mar 4, 2025 - "This study explores the combination of oncolytic adenoviruses with Erastin, a potent ferroptosis inducer, to enhance antitumor efficacy in oncolytic virus-insensitive cancer cell lines...This novel therapeutic approach has great potential to enhance the efficacy of oncolytic virotherapy in cancers resistant to oncolytic viruses by inducing ferroptosis. Further investigation in clinically relevant models is warranted to fully elucidate the underlying mechanisms and to optimize this combination strategy for potential clinical applications."
IO biomarker • Journal • Oncology • DKK1
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Fei Li; Jiaqi Ye; Shengfeng Xiong; Teng Ji; Wenhuan Li; Xiaohui Sun; Yao Si; Zhoutong Dai
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