Protective effect of 2-hydroxyestrone and 2-hydroxyestradiol against chemically induced hepatotoxicity in vitro and in vivo. (PubMed, J Pharmacol Exp Ther) - Mar 3, 2025 - "In this study, we seek to determine whether 2-hydroxyestrone (2-OH-E1) and 2-hydroxyestradiol (2-OH-E2), 2 major metabolites of endogenous estrone (E1) and 17β-estradiol (E2) formed by cytochrome P450 in the liver, can protect against erastin- and RSL3-induced ferroptosis in hepatoma cells (H-4-II-E and HuH-7) in vitro and acetaminophen-induced mouse liver injury in vivo. This study shows that 2-hydroxyestrone and 2-hydroxyestradiol are 2 inhibitors of PDI that can strongly protect against chemically induced ferroptotic hepatocyte death in vitro and in vivo. This work supports a PDI-mediated, estrogen receptor-independent mechanism of hepatocyte protection by 2-hydroxyestrone and 2-hydroxyestradiol."
Journal • Preclinical • Hepatocellular Cancer • Hepatology • Liver Cancer • Liver Failure • Solid Tumor • ER
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Bao Ting Zhu; Qi Zhang; Xi Sun; Xiangyu Hao; Yan-Yin Zhu; Yi-Chen Jia; Yong Xiao Yang
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