JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer. (PubMed, Cancer Res) - Feb 4, 2025 - "The JMJD6 antagonist SKLB325 synergized with erastin in multiple pre-clinical PCa models. Together, this study identifies JMJD6 as a druggable vulnerability in SPOP-mutated PCa to increase sensitivity to ferroptosis inducers."
Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • AR • ATF4 • MBD4 • MED1 • SLC7A11 • SPOP
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Chuanjie Zhang; Chufeng Chen; Da Huang; Dan-Feng Xu; Hai Huang; Hanqing Liu; Hongchao He; Jiawei Ding; Jun Xiao; Kiat Shenq Lim; Siqi Wu; Wenjie Zhou; Wenyu Miao; Yan Shen; Yi Gao
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