Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation. (PubMed, Front Pharmacol) - Jan 29, 2025 - "Moreover, the protective effect of PD is attenuated by erastin and resembled that of Fer-1 in caco-2 cells model...Further investigation into the precise mechanisms underlying this phenomenon is warranted. The findings presented herein indicated that PD may serve as a potential therapeutic agent for patients with UC."
Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • GPX4 • IL1B • IL6 • OCLN • SLC7A11 • TJP1 • TNFA
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Bingbing Wang; Hui Yue; Jialuo Huang; Jianbin Yin; Junfeng Wu; Qiujuan Ye; Shimin Zheng; Ting Zhang; Xinzhi Liang
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