Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway. (PubMed, Front Pharmacol) - Jan 28, 2025 - "The protein levels of SIRT1 and GPX4 were downregulated accompanied by the incremental concentrations of TGF-β or Erastin, which were repaired by DSI or Fer-1 intervention. However, the inhibition of ferroptosis and renal fibrosis owing to DSI were reversed by SIRT1 inhibitor EX527. Taken together, our results indicated that DSI could protect against ferroptosis to attenuate renal fibrosis by activating the SIRT1/GPX4 pathway. It is expected to be a potential agent to treat renal fibrosis."
Journal • Fibrosis • Immunology • Renal Disease • GPX4 • TGFB1
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Huan Zhao; Jingli Xiong; Jiuyao Zhou; Junbiao Wu; Junqi Chen; Lingru Zhao; Mingshan Zhang; Shuyin Lin; Yingqi Zhong; Yingru Su; Yiwen Cao; Yuan Zhou; Zhijun Zeng; Ziyu Long
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