Laminin-dystroglycan mediated ferroptosis in hemorrhagic shock and reperfusion induced-cognitive impairment through AMPK/Nrf2. (PubMed, Free Radic Biol Med) - Jan 27, 2025 - "Activating ferroptosis by erastin (a ferroptosis inducer) or inhibiting it by ferrostatin-1 (a ferroptosis inhibitor) respectively enhanced or mitigated cognitive deficits as well as the ferroptosis-related changes induced by HSR...The activation of astrocytes was significantly attenuated after Nrf2 knockout, associated with the increases of laminin-dystroglycan during astrocyte-neuron crosstalk. Thus, data from this study proposes a novel explanation, namely laminin-dystroglycan interactions during astrocytes-neurons crosstalk stimulating AMPK and Nrf2 induced neuronal ferroptosis, for the development of cognitive impairment after HSR."
Journal • Alzheimer's Disease • Cognitive Disorders • Hematological Disorders • Mood Disorders • AMPK • LAMA2 • TFRC
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Aoxue Xu; Chunxia Huang; Gordon Tin Chun Wong; Jia Hu; Kai Yuan; Lin Lu; Liyuan Guo; Lulu Liu; Qi Xue; Song Xue; Wei Liu; Wenping Lu; Xianwen Hu; Xiaoli Wu; Ye Zhang
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