Ferroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq. (PubMed, Antioxidants (Basel)) - Jan 26, 2025 - "Ferroptosis, a form of regulated cell death, can be induced in medulloblastoma cells in vitro using erastin or RSL3. This study demonstrates that the regulation of the ferroptosis transcriptional program is linked to medulloblastoma molecular subtypes and patient prognosis. A cross-validated ferroptosis signature was identified in two independent RNA-sequencing cohorts, and the ferroptosis score was confirmed as an independent and adverse prognostic factor in medulloblastoma."
Journal • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor • ATF4 • G3BP1 • IL6 • SLC39A1 • TFAP2A • TFAP2C
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Christophe Desterke; Claudia Monge; Jenny Bonifacio-Mundaca; Jorge Mata-Garrido; Pascal Pineau; Raquel Francés; Yuanji Fu
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