Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves' Ophthalmopathy. (PubMed, Invest Ophthalmol Vis Sci) - Jan 24, 2025 - "CCK-8 assays, flow cytometric analysis, and transmission electron microscopy (TEM) were used to compare the sensitivity of GO-OFs and control-OFs to erastin-induced ferroptosis. The viability and lipogenesis of the GO-OFs were significantly decreased, while the levels of ROS, lipid peroxidation, and the ferroptosis marker ACLS4 were increased upon treatment with simvastatin. Our study indicated that ferroptosis plays an important role in the pathogenesis of GO and that simvastatin may induce ferroptosis, suggesting that this drug could serve as a novel therapeutic agent for GO."
Journal • Endocrine Disorders • Grave's Disease • Ophthalmology • Thyroid Eye Disease
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Boding Tong; Dan Cao; Jing Deng; Lujue Wang; Tongxin Niu; Xin Qi; Yating Liu; Yongguang Tao; Yuan Li; Yunping Li; Yuxian Shi
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