Fabrication of a Redox-Reversible Near-Infrared Fluorogenic Probe for Ferroptosis Process Monitoring and the Early Diagnosis of Diabetes. (PubMed, Anal Chem) - Jan 22, 2025 - "With the help of NIR-CSTe, we observed that HT-1080 cells, induced to undergo ferroptosis by erastin after being washed with PBS for 24 h and then treated with ferrostatin-1, showed a recovery in intracellular GSH levels. In contrast, treatment with deferoxamine did not yield similar results. Lastly, NIR-CSTe was also utilized for the early diagnosis and efficacy assessment of diabetes in relation to ONOO-/GSH redox balance, with results illustrating that the combined administration of metformin and empagliflozin was more effective than using either drug alone. Thus, this smart probe holds significant potential as an essential tool for clinical diagnosis and treatment of diseases associated with redox homeostasis."
Journal • Diabetes • Metabolic Disorders
|
|
Fabiao Yu; Heng Liu; Jinsheng Wu; Lingchao He; Ningge Xu; Wei Zhang; Xiao Wei
|